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Bone mineral density and age-related maculopathy in older women. |
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OBJECTIVES: To determine whether bone mineral density (BMD) is associated with age-related maculopathy (ARM) risk in older women.
DESIGN: Cross-sectional analysis at Year 10 (1997/98) of the Study of Osteoporotic Fractures (SOF).
SETTING: Four clinical centers in the United States.
PARTICIPANTS: One thousand forty-two randomly sampled SOF participants who attended the Year 10 clinic visit.
MEASUREMENTS: ARM status was determined from fundus photographs using a modification of the Wisconsin Age-Related Maculopathy Grading System 6-level severity scale used in the National Health and Nutrition Examination Survey III. Total hip BMD was measured at Year 10 using dual-energy x-ray absorptiometry. Information on potential confounders, including age, reproductive hormone exposures, body mass index, smoking, alcohol consumption, nutrition, education, diabetes mellitus, hypertension, and physical activity, was ascertained with questionnaires.
RESULTS: The prevalence of ARM was 50% (46% had early ARM and 4% had late ARM). After potential confounder adjustment, greater BMD was associated with lower odds of ARM (odds ratio (OR) per 1 standard deviation increase in BMD=0.82, 95% confidence interval (CI)=0.70–0.96). Women in the highest quartile of BMD had lower odds of ARM than those in the lowest quartile (OR=0.63, 95% CI=0.41–0.97) and those in the lowest three quartiles combined (OR=0.66, 95% CI=0.48–0.91).
CONCLUSION: Higher levels of BMD may be associated with lower risk for ARM. The underlying mechanism is unknown, although BMD may be a marker for lifetime endogenous estrogen exposure. Future studies are needed to replicate these findings and further investigate the nature of the relationship between BMD and ARM.
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| Type |
Journal - Bibliographic Record |
Resource Type
(If applicable)
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| Author(s) |
Seitzman RL, Mangione CM, Cauley JA, Ensrud KE, Stone KL, Cummings SR, Hochberg MC, Hillier TA, Yu F, Coleman AL. |
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J Am Geriat Soc |
| Year |
2007 |
| Pages |
740–6 |
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| Edition |
55 |
Contact Information
(If applicable)
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Comments
(If applicable)
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National Resource Center on Nutrition, Physical Activity & Aging | Florida International University, OE 200, Miami, FL 33199
Phone: 305-348-1517 | Fax: 305-348-1518 | E-mail: nutrionandaging@fiu.edu
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